A micro pestle is a small laboratory tool used to grind, homogenize, and mix samples in small volumes (typically a few microliters). It is used in molecular biology and biochemistry experiments to prepare suspensions and extracts from tissues, cells, and microorganisms.

The micropestle is typically made of a metal or plastic rod with a rounded end and is used in conjunction with a microcentrifuge tube or well plate. The rounded end of the pestle is placed into the sample, and the tube or well is rotated or tapped to grind the sample against the pestle, resulting in a homogenized mixture.