A chromosome model is a representation or visualization of the physical structure of a chromosome. Chromosomes are structures found in the nucleus of a cell that carry genetic information in the form of DNA. A chromosome model can be a physical model, such as a 3D printed replica or a visual aid used in teaching or research, or a computer-generated model, such as a digital animation or simulation.

Chromosome models can be used to study the structure and function of chromosomes, the mechanisms of gene expression and regulation, and the effects of genetic mutations and variations.

They may incorporate different features of the chromosome, such as the double helix structure of DNA, the histone proteins that package the DNA, and the various types of genetic markers and modifications found on the chromosome.